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- Reversible gene knockdown in mice using a tight, inducible shRNAexpression system.
Seibler J, Kleinridders A, Kuter-Luks B, Niehaves S, Bruning JC, Schwenk F. (2007) Nucleic Acids Res., [Epub ahead of print]
- Single copy shRNA configuration for ubiquitous gene knockdown in mice.
Seibler, J., Kuter-Luks, B., Kern, H., Streu, S., Plum, L., Mauer, J., Kuhn, R., Bruning, J. C. and Schwenk F. Nucleic Acids Res., 33, e67. (2005)
- Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.
Schwenk F, Zevnik B, Bruning J, Rohl M, Willuweit A, Rode A, Hennek T, Kauselmann G, Jaenisch R, Kuhn R. Mol Cell Biol. 2003 Jun;23(11):3982-9
- Rapid generation of inducible mouse mutants.
Seibler J, Zevnik B, Kuter-Luks B, Andreas S, Kern H, Hennek T, Rode A, Heimann C, Faust N, Kauselmann G, Schoor M, Jaenisch R, Rajewsky K, Kuhn R, Schwenk F. Nucleic Acids Res. 2003 Feb 15;31(4):e12.
- Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation.
Eggan K, Rode A, Jentsch I, Samuel C, Hennek T, Tintrup H, Zevnik B, Erwin J, Loring J, Jackson-Grusby L, Speicher MR, Kuehn R, Jaenisch R. Nat Biotechnol. 2002 May;20(5):455-9.
- BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L. Hum Mol Genet. 2001 Jun 1;10(12):1317-24.
- Conditional knockout mice.
Kuhn R, Schwenk F. Methods Mol Biol. 2003;209:159-85.
- Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells.
Andreas S, Schwenk F, Kuter-Luks B, Faust N, Kuhn R Nucleic Acids Res. 2002 Jun 1;30(11):2299-306.
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TECHNOLOGY
