Prof. Klaus Rajewsky, MD
Center for Blood Research and Professor of Pathology, Harvard Medical School
Dr. Klaus Rajewsky was a co-founder of ARTEMIS in 1998. Dr. Rajewsky is the inventor of the Cre-lox technology for making conditional gene knock-outs in mice, and is a world leader in the field of mouse genetics and B lymphocyte development. Dr. Rajewsky and his team have developed a range of tools which allow genes to be switched on or off at any time in selected cells of the adult mouse. This makes a general mutation analysis of life processes in the mouse possible, which was still inconceivable only a short while ago. He studied medicine and chemistry in Frankfurt and Munich. After a research visit to the Institute Pasteur in Paris he began his scientific work at the Institute for Genetics at the University of Cologne in 1964, which he has directed since 1970. Dr.Rajewsky is a member of the European Molecular Biology Organization (EMBO) and member of the National Academy of Sciences. His numerous scientific awards include the Aery Landsteiner prize (1977), the Bering Kitasato prize (1994), the Robert Pfleger prize (1994), the Robert Koch prize (1996) and the Kröber prize for European science (1997). He is the author of more than 280 articles in leading scientific journals. He is on the editorial board of renowned journals such as ‘The EMBO Journal’, ‘Journal of Experimental Medicine’ and ‘Cell’.
Prof. Rudolf Jaenisch, MD
Whitehead Institute and Professor of Biology, MIT
Dr. Rudolf Jaenisch has been a scientific advisor to ARTEMIS since May 1999. Dr. Jaenisch is one of the founders of transgenic science. A world leader in the field of transgenic technology and the study of epigenetic reprogramming during development, he has made important contributions to the field of nuclear transplantation. He is a founding Member of the Whitehead Institute and professor of biology at MIT. Prior to the Whitehead, he was head of the Department of Tumor Virology at the Heinrich Petter Institute at the University of Hamburg, Germany. Dr Jaenisch is a fellow of the American Academy of Arts and Sciences and the American Academy of Microbiology and a member of the American Association for the Advancement of Science. In 1996 he was awarded the Boehringer Mannheim Molecular Bioanalytics Prize. He received his doctorate in medicine from the University of Munich in 1967.
Prof. A.Francis Stewart, Ph.D
Institute of Genomics, BioinnovationZentrum, University of Technology, Dresden
Dr. Francis Stewart has been a scientific advisor to ARTEMIS since 1999. Dr. Stewart pioneered several advanced strategies of genome engineering and conditional mutagenesis for the mouse and other living systems. These include ligand regulated site specific recombination using Cre-steroid hormone receptor fusion proteins; the development of efficient FLP recombination by application of molecular evolution to obtain FLPe; and 'recombineering' - the use of homologous recombination by the lambda phage Red operon in E.coli for DNA engineering, particularly BACs (bacterial artificial chromosomes). Consequently, he pioneered the use of large, BAC-based targeting constructs for homologous recombination to engineer the mouse genome. Beyond technology development, he studies epigenetic mechanisms in chromatin, more specifically nucleosome modifications and trithorax-Group action. Dr. Stewart became the Founding Professor for Genomics at the University of Technology, Dresden, in 2001. Previously he was a Group Leader at EMBL, Heidelberg. He obtained his Ph.D from the University of New South Wales, Sydney, Australia, in 1986.
TECHNOLOGY
